| abstract |
Process for the preparation of 25-cyclohexyl-22,23-dihydro-5-hydroxyiminoavermectin B1 monosaccharide from doramectin in 4 steps. Catalytic hydrogenation in an organic solvent, oxidation with manganese dioxide in an organic solvent, reaction with hydroxylamine hydrochloride in an aqueous organic solvent, and optionally recrystallization of the product from toluene or methanol. Also described are its intermediates and crystalline solvates which are active as antiparasitic agents. |