| abstract |
Described are compounds of formula (I) wherein B is O or CH 2, X is selected from NR 1 R 2, SR 1 and C 1 -C 7 alkyl, Y is selected from SR 1, NR 1 R 2 and C 1 -C 7 alkyl, R 1 and R 2 are each independently selected from H or C 1 -C 7 alkyl optionally substituted on the alkyl chain by one or more O, S, N or halogen, R 3 and R 4 are both H, or R 3 and R 4 together form a bond, A is COOH, C (O) NH (CH 2) p COOH , C (O) N [(CH 2) q COOH] 2, C (O) NHCH (COOH) (CH 2) r COOH or 5-tetrazolyl, wherein p, q and r are each independently 1, 2 or 3, processes for their preparation, intermediates to this preparation as well as their pharmaceutically acceptable salts, their esters and amides, the pharmaceutical compositions containing them and their use for the preparation of a medicament, in particular for the prevention of platelet aggregation. |