| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0597f9c318d2aeca86db94711c516383 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-839 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-475
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-475 |
| filingDate |
1995-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b3b22aa28c5b84a121daf18ef745ecf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_843b204c2dd92afb678ba5427603eb10 |
| publicationDate |
2003-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
SK-283083-B6 |
| titleOfInvention |
Polyethylene glycol derivative polypeptide, method of attaching polyethylene glycol to a polypeptide and a homogeneous preparation of monopegylated BDNF and NT-3 |
| abstract |
A polyethylene glycol derivative of a polypeptide selected from the group consisting of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), wherein the polypeptide is attached to polyethylene glycol is disclosed. A method of attaching a polyethylene glycol comprising one reactive aldehyde group to a polypeptide selected from the group consisting of BDNF and NT-3, wherein the polypeptide is reacted with polyethylene glycol under reductive alkylation conditions and at a pH value that is sufficiently acidic to provide the α-amino group on N the end of the polypeptide reactivity to attach the polyethylene glycol to the alpha-amino group. A homogeneous preparation of BDNF or NT-3, which are monopegylated at the α-alpha-amino group at the N-terminus for use in the treatment of impaired motoneurons and to improve brain tissue migration of BDNF or NT-3. |
| priorityDate |
1994-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |