| abstract |
Compounds of formula (I) wherein X is hydrogen, halogen or alkyl, alkoxy, trifluoromethyl or phenylmethoxy, R1 is hydrogen or alkyl, cyclopropyl or phenylmethyl, R2 is either optionally substituted alkyl or optionally substituted phenylalkyl, or cyclohexylmethyl, or thienylmethyl, or pyridinylmethyl or optionally substituted phenyl, or pyridinyl, or 5-methyl-1,2-oxazolyl, or 5-methyl-1,3,4-thiadiazolyl, or naphthyl, R 3 and R 4 are hydrogen, alkyl, 2-methoxyethyl, hydroxyalkyl, carboxyalkyl, alkoxycarbonylalkyl or phenylalkyl, or R 3 and R 4 together with the nitrogen atom to which they are attached form either an optionally substituted pyrrolidinyl or piperidinyl, or morpholinyl, or 4-methylpiperazinyl, or azetidinyl, or thiazolidinyl, and a carbon-3 linkage it is single or double; a process for the preparation of these compounds and a pharmaceutical composition containing them |