| abstract |
The heterocyclic compound of formula (I), or a pharmaceutically acceptable acid addition salt thereof, wherein R 1, R 2, R 3 and R 4 are each independently H, C 1-4 alkyl or C 1-4 alkoxy; R 5 and R 6 are each independently H or C 1-4 alkyl; X is O S (O) n or NR 7; Y is O, S (O) n or NR 8; R 7 is H or C 1-4 alkyl; R 8 is H or C 1-4 alkyl; n is 0, 1 or 2, wherein when X is NH, Y is NH and R1, R3 and R4 is H, then R2 is not methoxy or ethoxy, and if X is NH and Y is S then at least one of R1, R2, R3 and R4 are not H. A pharmaceutical composition based on these compounds and their use in the manufacture of a medicament for inhibiting leukocyte adhesion to endothelial cells, treating inflammatory diseases and treating HIV infections. |