| abstract |
N-substituted 2-cyanopyrrolidines of formula (I) which inhibit DPP-IV (dipeptidyl peptidase-IV) activity and are suitable for use as medicaments for inhibiting DPP-IV and in the treatment of conditions mediated by DPP-IV such as non-insulin-dependent diabetes , arthritis, obesity, osteoporosis and other conditions of impaired glucose tolerance; the method of preparation thereof; intermediates therefor; a pharmaceutical composition comprising compounds of formula (I) and their use |