| abstract |
Azole compounds of formula (II) wherein R 1 is chloro, fluoro or trifluoromethyl; R 2 is hydrogen, chloro, fluoro or trifluoromethyl; Z is CH or N; R 3, R 4 and R 5, the same or different, are hydrogen or C 1 -C 4 alkyl, provided that R 4 is other than R 5 when R 3 is hydrogen; X is O or S; R 6 is a C 1 -C 5 polyfluoroalkyl group containing at least two fluorine atoms and optionally other halogen atoms selected from chlorine and bromine; and salts thereof with pharmaceutically acceptable acids for use as medicaments; a pharmaceutical composition comprising them. The compounds of formula (II) have antifungal activity for use in human medicine and veterinary medicine. |