| abstract |
Compounds of formula (I) are described wherein R 1, R 2 and R 3 are as defined herein, R 4 and R 5 are each hydrogen, (C 1 -C 6) alkyl, fluoro, chloro, hydroxyl, (C 1 -C 3) alkoxy , amino, optionally (C1-C3) -alkyl substituted or (C1-C4) -perfluoroalkyl, R6 and R7 are each hydrogen or (C1-C4) -alkyl and X is oxygen, imino or (C1-C4) -alkylimino as well as their pharmaceutically acceptable salts, process for the preparation of these compounds and medicaments containing them. These compounds are potent inhibitors of the Na + / H + cell exchange system and are therefore very useful in the treatment of diseases associated with increased Na + / H + exchange. |