| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0d4f0e254c73f422758c61fb7bb0f991 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-93 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 |
| filingDate |
2002-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_917607433ad17830efed25de7f745340
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bff3304fc658cd03dd1cbda8180e5fa9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af31b9e60302ec1755d912084d839548
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5e570258d8bfe3b05c88442ca09b4fb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58f5c2cba697cc2acc49f1a5455f3195
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ef3ba21e164205451d5f1c93ff6814a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9390363d8e2ac933e2a5bea648d5b3c9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ca187798c85e038ef77e286cda23806
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e224e7d65d620dd7540fbdbb32ed06e4 |
| publicationDate |
2005-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
SK-282004-A3 |
| titleOfInvention |
A method of designing a drug structure for identifying D-Ala-D-Ala ligase inhibitors as antibacterial drugs |
| abstract |
The invention is based on the discovery that certain small molecules can bind to the ATP binding site of D-Ala-D-Ala ligase, even in the absence of the enzyme's substrate, and can cause a conformational change in the enzyme structure similar to that which occurs upon binding of ATP and substrate to the enzyme. Without wishing to be bound by any theory, it is believed that such a conformational change is required for either activation or inhibition of the enzyme. The information obtained from this discovery has enabled identification of key interactions in the active site of the enzyme, as well as the design and opimization of inhibitors. |
| priorityDate |
2001-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |