| abstract |
Disclosed are pyrrolecarboxamides of formula (II) wherein R 1 is phenyl optionally substituted with fluoro, chloro or bromo; R 2 and R 3 are each independently hydrogen, C 1 -C 6 alkyl, phenyl optionally substituted by fluorine, chlorine or bromine, or -CONR 5 R 6, wherein R 5 and R 6 are each independently H or phenyl; optionally substituted with fluorine, chlorine or bromine; R 4 is C 1 -C 4 alkyl; and R 8 and R 9 are each phenyl. These pyrrolecarboxamides are hypolipidemic and hypocholesterolemic active and can also be used as intermediates for the production of trans-6- [2- (substituted pyrrol-1-yl) alkyl] pyran-2-ones, which are also hypolipidemic and hypocholesterolemic agents. |