| abstract |
A process for the preparation of 3- {2- [4- (6-fluorobenzo [d] isoxazol-3-yl) piperidin-1-yl] ethyl} -2-methyl-6,7,8,9-tetrahydro-4H- pyridol [1,2-a] pyrimidin-4-one of formula (I) by the reaction of 3- (2-aminoethyl) -2-methyl-6,7,8,9-tetrahydro-4H-pyrido [1,2-a] ] pyrimidin-4-one of formula (II) with a compound of formula (III), wherein Y and Z represent the same or different release of a group such as halogen or a C 1-6 alkyl or phenylsulfonyloxy group in the presence of a solvent and a base. Further described are compounds of formula (II) and formula (III), wherein Z and Y are as defined, as intermediates in a process for the preparation of a compound of formula (I). |