| abstract |
Described are 4-substituted piperidine derivatives of formula (I) wherein m is 2 or 3, D is a nitrogen-containing moiety, G is a single bond, a double bond or a divalent hydrocarbon moiety, J is a ring bonded moiety in the case of wherein G is a double bond, or in other cases a double bond moiety, M is a hoteroatom or a substituted heteroatom, L is a hydrocarbon moiety whose position 1 is bonded to M, their N-oxides, and pharmaceutically acceptable salts thereof. These compounds are non-peptide neurokinin A antagonists and are useful in the treatment of asthma and related conditions. Also described are pharmaceutical compositions containing the compounds and methods for making the compounds |