abstract |
A process for preparing 2,6-dichloro-5-fluoronicotinic acid, comprising reacting a 2,6-dihydroxy-5-fluoronicotinic acid ester with POCl 3 in the presence of a lithium reagent to give 2,6-dichloro-5-fluoronicotinoyl chloride, followed by basic hydrolysis of said of product, 2,6-dichloro-5-fluoronicotinic acid is obtained |