| abstract |
Disclosed is a derivative of formula (I) wherein -A = B-C = D- is -CH = CH-CH = CH- wherein optionally 1 or 2 CH are replaced by N; Ar is phenyl or naphthyl optionally substituted or 1, 2 or 3 H, Q, phenyl or NR 4 R 5; R1, R2, R3 independently of each other are H, Hal or Q; R4 and R5 are independently H or Q; Q is C 1-6 alkyl; X is O or S; Hal is F, Cl, Br or J; n is 1, 2 or 3; and its salts are suitable for the manufacture of pharmaceutical compositions for endothelin receptor antagonist properties |