abstract |
Peptides of the formula (I) in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, aryl, arylsulphonyl, heteroaryl or the residual of an amino acid, each of which can optionally be substituted; B is the residual of a basic amino acid; C is the residual of a di- or tripeptide; E is the residual of an aromatic amino acid; F is, independently of one another, an amino acid which is optionally substituted in the side chain or is a direct bond; G is the residual of an amino acid; F' is defined as F and it can be -NH-(CH2)2-8 or optionally a direct bond; I is -OH, -NH2 or -NHC2H5; K is a radical -NH(CH2)1-4 -CO- or is a direct bond, have bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are promoted, induced or sustained by bradykinin and bradykinin-related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis. |