| abstract |
N-Benzylindoles having the formula (I) in which R1 is hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, a cyano group, carboxy, tetrazolyl, trihalogenmethyl, hydroxy-C1-4 alkyl, formyl, -CH2Z group, -CH=CH-Z or -CH2CH2Z where Z is carboxy or tetrazolyl; R2 is halogen, a cyano group, carboxy, tetrazolyl or -CONR7R8 group where R7 and R8 are each hydrogen or C1-4 alkyl, R3 and R4 are each hydrogen, C1-4 alkyl, optionally substituted phenyl, or substituted C1-4 alkyl, C1-4 alkoxy; R5 represents a group of the formula (a), (b), (c) or (d), where W is -CH=CH-, -CH=N-, -N=CH-, -O- or -S-, R9 is hydrogen, halogen, C1-4 alkenyl, C1-4 alkoxy or trihalogenmethyl, and R10 is hydrogen, C1-4 alkyl, C2-6 alkenyl, C3-6 cycloalkyl or C1-4 alkyl-C3-6 cycloalkyl; R6 is hydrogen or C1-4 alkyl; X is -O-(CH2)nCR11R12-, -CR11R12-, -CR11R12.(CH2)n.CR13R14- or -CR11=CR12-, where R11, R12, R13 and R14 are each hydrogen or C1-4 alkyl, and n is 0, 1 or 2; and Y is -O-CR15R16-, -CR15=CR16- or -CR15R16.CR17R18-, where R15, R16, R17 and R18 are each hydrogen or C1-4 alkyl; or a salt thereof. The compounds in unprotected form are active as leukotriene antagonists. |