http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SK-278225-B6
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C50-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C46-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C50-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C50-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-727 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J27-128 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-423 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C46-00 |
| filingDate | 1990-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ce4ca6ef71582c8df19d02a90f3c355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed1bc3695ba6d9b2ea95f36a9e24ca1d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98ccbb67fe1f7d59148841318d2aef43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9b5833d7c03522b919db98322fa02eb |
| publicationDate | 1996-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SK-278225-B6 |
| titleOfInvention | Process for preparing anthracyclinones. |
| abstract | METHOD FOR PREPARATION OF ANTHRACYCLINONES The preparation method of anthracyclinones of the general formula I, wherein R means group of the formula COOR1, in which R1 means a hydrogen atom or methyl, resides in following: in the first stage the 13-keto group of the 4-demethyl-3- -deoxydaunomycinone is protected by working up with the ethylene glycol; in the second stage the resultant 4-demethyl-13- -dioxolanyl-7-deoxydaunomycinone reacts with the sulphonatic agent of the formula R'-SO2-X, in which X means the halogene atom or the group of the formula -O-SO2-R' and R' means the trifluoromethyl, p-fluorophenyl or p-tolyl group; in the third stage the resultant 4-demethyl-13-dioxolanyl-7- -deoxydaunomycinone of the general formula V reacts with the nucleophilic agent of the general formula R1OH in which R1 has a meaning listed above, and with the carbon monoxyde under presence of the triethylamine and the catalitic amount of the palladium complex with chelating ligand; and in the fourth stage the resultant 4-demethyl-4-carboxyalkyl-7-deoxy-13- -dioxolanyldaunomycinone of the general formula VII reacts with the bromine solution in the carbon tetrachloride for introduction of the alpha-hydroxy group into the position 7 of the general formula VII compound, then the 13-dioxolanyl protective group is removal and, after chromatographic treatment the required pure compound of the general formula I is obtained. |
| priorityDate | 1989-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 85.