| abstract |
Phenyl-imidazo (1,2-a) pyridine derivs. of formula (I) and their corresponding 5,6,7,8-tetrahydro-imidazo (1,2-a) pyridine derivs. and their salts and/or solvates are new:R = Q or COX; R<1> = Q if R = COX and COX if R = Q; Q = NO2, NH2, CN, CSNH2, C(=NH)SA, C(=NH)NHOH,etc., or D; D = a gp. of formula (a):X = OH, OA, AS, ASAS<1> or a gp. of formula (b) or (c):AS or AS<1> = aminoacid gp. chosen from Ala, beta -Ala, Arg, Asn, Asp, Gln, Glu, Gly,etc., and N-phenethyl- beta -Ala and any free amino or carboxyl gps. are opt. protected; R<2> = OH, A or Ar; R<3> = (CH2)mCOOR<5>; R<4> = (CH2)pCOOR<5> or (CH2)qO(CH2)rCOOR<5>; R<5> = H or A; m = 1-3; n = 1-4; p = 0-2; q = 0-1; r = 1-2; A = 1-6C alkyl; alk = 1-6C alkylene; Ar = phenylene. |