| abstract |
Disclosed are dihydrobenzopyran derivatives of general formula (I), wherein R1, R2 an R3 each independently is H or C1-6 alkyl; R4 is halogen, C1-6 alkyl, hydroxy, C1-6 alkoxy, aryloxy or arylmethoxy; R5 and R6 are R5b and R6b, wherein R5b is H and R6b is heterocyclic residue or eventually substituted alkenyl or alkinyl, or R5 and R6 are R5c and R6c, whilst in this case R4 is only H and R5c and R6c is each independently H, halogen, C1-6 alkyl, C3-6 alkenyl, hydroxy, C1-6 alkoxy, cyano, C1-6 aminoalkyl, carboxy, C1-6 alkoxycarbonyl in alkoxyl, nitro, amino, aminocarbonyl, C1-6 alkylcarbonylamino in alkyl or mono- or di(alkyl)amino with C1-6 in each of alkyls; Q is heterocyclic ring containing at least one nitrogen or residue of general formula (aa) and their pharmaceutically suitable additive salts with acids or bases and their stereochemically isomeric forms; their production method, intermediates of general formula (V-a), compounds of formula (I) for use in medicine and pharmaceutical preparations based on them, particularly for prevention and/ or treatment of defects characterised by over-vasodilatation, particularly migraine. |