abstract |
The invention provides enhanced LM609 grafted antibodies exhibiting selective binding affinity to alpha >v< beta >3<, or a functional fragment thereof. The invention also provides nucleic acid molecules encoding the enhanced LM609 grafted antibodies. Additionally provided are methods of inhibiting a function of alpha >v< beta >3< by contacting alpha >v< beta >3< with an enhanced LM609 grafted antibody. |