| abstract |
Arylalkanoylpyridasine derivative of general formula (I), wherein B is A, OA, NH2, NHA, NAA', or unsaturated heterocycle with 1 to 4 atoms of N, O and/ or S, substituted eventually by 1 to 3 groups from Hal complex, A and/ or OA; Q is absent or means C1-6alkylene; R1, R2 are independently OH, OR5, -S-R5, -SO-R5, -SO2-R5, Hal, NO2, NH2, NHR5 or -NR5R6, or R1 and R2 together are -CH2-O-; R5 and R6 are independently A, C3-8cycloalkyl, methylene-C4-8cycloalkyl or C2-8alkenyl; A, A' are independently C1-10alkyl substituted eventually by 1 to 5 F and/ or Cl; Hal is F, Cl, Br or I, and physiologically suitable salts, which are as retrograde substances of phosphodiesterasis IV suitable for production of pharmaceutical preparations for treatment of e. g. asthma, allergies and inflammatory diseases, autoimmune diseases and transplantate-refusing reactions; its production method and pharmaceutical preparation containing it. |