http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SK-145792-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a717ea5b2ac78ac329ab3a9659d834d2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 |
| filingDate | 1992-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_345e5d7b53d8ebc8e1ad49972e070fe5 |
| publicationDate | 1995-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SK-145792-A3 |
| titleOfInvention | Rapamycin derivatives and pharmaceutical agents containing them |
| abstract | The invention concerns a compound of the structure <CHEM> wherein R<1> and R<2> are each independently, hydrogen or <CHEM> X is -(CH2)m- or -Ar<1>- ; R<3> and R<4> are each, independently, hydrogen, alkyl, -(CH2)n-Ar, -(CH2)p-NR<5>R<6>, or -(CH2)p-N<+>R<5>R<6>R<7>Y<-> ; R<5> and R<6> are each, independently, hydrogen, alkyl, or -(CH2)n-Ar; Ar- and -Ar<1>- are each optionally substituted mono- or bivalent radicals respectively of groups selected from <CHEM> <CHEM> in which the optional substituents are selected from the group consisting of alkyl, aralkyl, alkoxy, cyano, halo, nitro, carbalkoxy, or perfluoroalkyl; R<7> is alkyl; Y is a halide, sulfate, phosphate, or p-toluenesulfonate anion; m = 1 -6; n = 1-6; p = 1 -6; with the proviso that R<1> and R<2> are not both hydrogen; or a pharmaceutically acceptable salt thereof, which by virtue of its immunosuppressive activity is useful in treating transplantation rejection, host vs. graft disease, autoimmune diseases and diseases of inflammation; by virtue of its antitumor activity is useful in treating solid tumors; and by virtue of its antifungal activity is useful in treating fungal infections. |
| priorityDate | 1991-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.