| abstract |
1-Ä omega -(3,4-Dihydro-2-naphthalenyl)alkylÜ cyclic amine derivatives represented by general formula (I) and salts and N-oxide derivatives thereof, wherein R<1> and R<2> represent each hydrogen, halogeno, hydroxy, alkyl, alkoxy, hydroxymethyl, etc., or R<1> and R<2> form together methylenedioxy, trimethylene, etc.; R<3> represents hydrogen, etc.; R<4> represents hydrogen, hydroxy, alkyl, etc.; R<5> represents hydrogen, alkyl, etc.; p is an integer of from 2 to 6; and q is an integer of from 3 to 7; excluding the case where R<1>, R<2>, R<3>, R<4> and R<5> are all hydrogen, p is 2 and q is 5. The compounds have a potent effect of suppressing urinary reflex and thus are useful as a remedy for frequent urination and urinary incontinence. <CHEM> |