| abstract |
The present invention relates to compounds of formula (I), wherein n is 0-6; X is CH2, CH2CH2 or oxygen; Z is CHR<2> or NR<2>; R<1> and R<2> are selected independently from hydrogen, (C1-C6)alkyl, aryl and heteroaryl, wherein said aryl is selected from phenyl and naphthyl and said heteroaryl is selected from 5 and 6 membered aromatic heterocyclic rings that contain from one to four heteroatoms selected, independently, from nitrogen, oxygen and sulfur, and wherein said aryl and heteroaryl moieties can optionally be substituted with one or more substituents that are selected, independently, from halo, -S(C1-C6)alkyl, -S(O)(C1-C6)alkyl, -S(O)2(C1-C6)alkyl, (C1-C6)alkyl optionally substituted with from one to seven fluorine atoms, (C1-C6)alkoxy optionally substituted with from one to seven fluorine atoms, amino, nitro, cyano, carboxy, -CO2(C1-C6)alkyl, (C1-C6)alkylamino, di-[(C1-C6)alkyl]amino phenoxy, anilino and phenylthio; pharmaceutical compositions containing such compounds (I) and the use of such compounds (I) to treat neurological and psychiatric disorders. |