| abstract |
Diaryl dicarboxylic acid diguanidines of formula (I) and their salts are new. One of R1-R5 and one of R6-R10 = CON=C(NH2)2; of the others, R1, R5, R6, R10 = H, 1-4C alkyl, F, Cl, OR32, NR33R34 or CF3; R32-R34 = H or 1-4C alkyl; R2, R4, R7, R9 = H, F, Cl, Br, I, OH, CN, CF3, CON=C(NH2)2, 1-8C alkyl, 2-8C alkenyl, (CH2)mR14, pyrrol-(1, 2 or 3)-yl (optionally mono- to tetra-substituted by F, Cl, Br, I, CN, 2-8C alkanoyl, 2-8C alkoxycarbonyl, formyl, carboxy, CF3, methyl or methoxy), SO2R22, CONR23R24, COR28, SO2N(R29)R30, OR35 or N(R35)R36; m = 0-2; R14 = 3-8C cycloalkyl or phenyl (optionally mono- - tri-substituted with F, Cl, CF3, methyl, methoxy or N(R15)R16); R15, R16, R23, R24, R29, R30 = H or CH3; R22, R28 = methyl or CF3; R35, R36 = H or 1-6C alkyl; or R35+R36 = 4-7 methylene (optionally with one group substituted by O, S, NH, NCH3 or N-benzyl); R3 = H, SR25, OR25, N(R25)R26, C(R25)(R26)R27; R25 = H, 1-8C alkyl, phenyl (optionally mono- to tri-substituted with F, Cl, CF3, CH3, methoxy, hydroxy, amino, methylamino or dimethylamino), or 1-9C heteroaryl (optionally mono- to tri-substituted by F, Cl, CF3, CH3, OMe, OH, NH2, NHCH3, N(CH3)2); R26, R27 = as R25, or H or 1-8C alkyl; A = bond, N(R11)CO, N(R12)CON(R13), N(R17)CON(R18)SO2, N(R19)SO2, SO2, SO2N(R19)CO, OCON(R19)SO2 or C(R20)=C(R21); and R11 - R21 = H or 1-8C alkyl. |