| abstract |
Compounds having the structure <CHEM> wherein (Z &rparstr& COO is the residue of an iodinated aromatic acid; n is an integer from 0 to 20; R<1> and R<2> are independently H, alkyl, fluoro-alkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy; R<3> and R<4> are independently a substituent as defined for R<1> and R<2> above, halogen, hydroxy or an acylamino; and R<5> and R<6> are independently H, alkyl, cycloalkyl, aryl, aralkyl, alkoxy, alkoxyalkyl, or acetamidoalkyl; or R<5> and R<6>, taken together with the nitrogen atom to which they are attached, represent a 4 to 7-membered nitrogen containing ring, are useful as contrast agents in x-ray imaging compositions and methods for x-ray diagnostic imaging. |