| abstract |
Compounds of the formula (I) or a pharmaceutically acceptable salt or isomer thereof are disclosed, wherein: Q, X and Z are CH or N; R, R 4 -R 7 and R 13 are H or alkyl; R 1 is H, alkyl, fluoroalkyl, R 9 -arylalkyl, R 9 -heteroarylalkyl, alkyl-SO 2 -, cycloalkyl-SO 2 -, fluoroalkyl-SO 2 -, R 9 -aryl-SO 2 -, R 9 -heteroaryl-SO 2 -, N(R 22 )(R 23 )-SO 2 -, alkyl-C(O)-, cycloalkyl-C(O)-, fluoroalkyl-C(O)-, R 9 -aryl-C(O)-, NH-alkyl-C(O)- or R 9 -aryl-NH-C(O)-; R 2 is H and R 3 is H, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, R 9 -aryl, R 9 -arylalkyl, R 9 -heteroaryl, or R 9 -heteroarylalkyl, and when X and Z are each CH, R 3 is alkoxy, R 9 -aryloxy, R 9 -heteroaryloxy, alkylC(O)O-, alkylaminoC(O)O-, alkylC(O)NR 13 -, alkylOC(O)NR 13 - or alklaminoC(O)NR 13 -; or R 2 and R 3 together are = O, = NOR 10 , = N-NR 11 R 12 or = CH-alkyl; R 8 is substituted phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenymethyl, alpha-substituted benzyl or alpha-substituted heteroarylmethyl; R 9 -R 12 are as defined; are disclosed for the treatment of HIV in combination with specified antiviral agents. |