| abstract |
Hybrid protein composed of two coexprimed amino acid sequences generating dimer, each of which contains (a) at least one amino acid sequence from the following: homomerous receptor, chain of homomerous receptor, ligand or their fragments, which kept their ability of the bond ligand-receptor and (b) sub-unit of heterodimerous protein hormone or its fragment which keeps the ability to form heterodimer with the same sub-unit, where the sequence (a) and (b) are bond directly or through the peptide linker, and where the sequence (b) in each of the said coexprimed sequences is able to aggregate with the occurance of dimerous complex. Disclosed is also DNA molecule, which encodes hybrid protein, express vector, which contains DNA molecule, host cell, which contains express vector, production method of hybrid protein and pharmaceutical mixture containing hybrid protein and pharmaceutically acceptable carrier and/ or vehiculum. |