| abstract |
L-arginine derivatives of general formula (I), a method for preparing same, and pharmaceutical compositions containing said d erivatives, are disclosed. Such compounds are biologically active as nitric oxide synthase inhibitors. In the general formula, A i s a hydrogen atom, a lower alkyl grouping or a nitro radical, E i s an oxygen atom or a covalent bond, n is 0 or an integer from 1 to 12, and each of R1 and R2 is a straight or branched alkyl chai n, or R1 and R2, taken together with the nitrogen atom to which t hey are attached, form a saturated or unsaturated 5- or 6-membere d ring of formula (a), wherein X is a hydrogen, sulphur or nitrog en atom or an imino, alkylimino or methylene radical. |