| abstract |
Provided herein are novel syntheses of the phosphate-based inositol derivatives 1-O-[(+)-menthoxycarbonyl]-6-O-benzyl-2,3:4,5-di-O-isopropylidene-myo-inositol (D4P), D-myo-inositol 1,4,5-triphosphate (D-IP3), 6-O-benzyl-2,3:4,5-di-O-isopropylidene-myo-inositol H-phosphonate (3-HP) and L-myo-inositol 1,4,5-triphosphate (L-IP3). These syntheses employ fewer column chromatography steps for the isolation of intermediates than do prior art syntheses, and hence, are more convenient, economical and efficient than are the previously known synthetic methods. |