abstract |
Novel compounds of formula (i): chemical agents. New compounds with iormuio (i) so ie aeincompounds of formula (II):nAnOhnin which A represents -C = CH-B, -C-C = CH-B, - (CH2) o-2-nΧ-Β, optional subst. heteroaryl, benzofused heteroaryl,n-C (O) -B or - (CH2) | _2 · Ν ^^ η, 3nwherein B is optionally substituted phenyl and X represents a bond,n-NH- or -S (O) 0-2-; D is preferably B- (CH2) 2-e- ornB- (CH2) o-5-Z- (CH2) o-5-wherein B is naphthyl, optionally subst.nheteroaryl or optionally subst. phenyl and Z represents -O-,n-C (O) -, phenylene, -NRe- or -S (O) 0-2-; R is H, F,nalkyl, alkenyl, alkynyl or B- (CH2) o-3-; AND R4 is optionalnsubst. phenyl, heteroaryl or benzofused heteroaryl; sondescribed, as well as their use as hypocholesterolemicsnof which: R21 is H and E is a bond or lowernalkylene, or P.21 means phenyl! and E jc lower aikiien; R22 isnH and F are a bond; G is a bond, R23 is optionally subst. phenyl; innR20 is optionally subst. phenyl. Some compounds withnof formula (II) which do not belong to the compounds of formula (I) arennew compounds. Processes for the production of the compounds describednin the invention, contain, as a main step, cyclizationnstereoselectively prepared hydroxyamide withnformula: |