http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SI-9111719-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68cfa36b88a3869912ccc31dab628643 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ad3d51747a2eba1e7636894263252df4 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 |
| filingDate | 1991-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfb3e63bc31ac389f140df219b9db56a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_263ce7cb6e002421693ef28efe23b45d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd4fdbe9c2f454813e6b239c11755605 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_864ce5b9db77fb04fc8f2b3ad1148865 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4a5897464cf44fb9effb7e4078bb14d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f09713e15d8270351b2b325dccda72f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9d579c4864a21142f8d77d4749f2ed2 |
| publicationDate | 1998-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SI-9111719-A |
| titleOfInvention | New N- (1,3-dihydro-2H-benzo-1,4-diazepine-1 (or 3) -acyl) -amino acids and -dipeptides, their derivatives, processes for their preparation and pharmaceutical preparations contained therein |
| abstract | Novel N- (1,3-dihydro-2H-benzo-1,4-benzo-1,4-diazepin-1 (or 3) -ylacyl) -amino acids and -dipeptides, their derivatives, processes for their preparation and pharmaceutical preparations containing them. Described are compounds of formula I in which one of R 1 and R 2, which are different, is hydrogen, straight or branched C 1 -C 16 -alkyl, C 4 -C 7 -cycloalkyl or benzyl and another group of formula II wherein m is 1,2 or 3, n 0,1 or 2, R 5 hydrogen, unbranched or branched C1-C6-alkyl, C4-C7-cycloalkyl, hydroxymethyl, fluoromethyl, trifluoromethyl, azidomethyl or C1-C4-alkoxymethyl group, group -COOH, -COOCH3, -COOCH2CH3 , -COOCH2C6H5 or -CONH2; R 6 is a group -OH, -OCH 3, -OCH 2 CH 3, -OCH 2 C 6 H 5, -NH 2 or a group of formula III in which R 7 represents a group -COOH, -COOCH 3, -COOCH 2 CH 3, -COOCH 2 C 6 H 5 or -CONH 2 and R 8 a group -OH, -OCH 3, -OCH 3 , -OCH2C6H5 or -NH2; R3 is phenyl, substituted phenyl, unbranched or branched C1-C16-alkyl or C4-C7-cycloalkyl and R4 is hydrogen, halogen, -NO2, -CF3, -NHCOCH3, -OH or OR, wherein R is unbranched or branched C1-C4 -alkyl. These compounds have immunomodulatory, antitumor, anxiolytic, hypnotic, antigastric, anticholecystokininic and other pharmacological effects. Also described are processes for the preparation of compounds of formula I and pharmaceutical preparations containing them as active ingredients. |
| priorityDate | 1991-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 87.