http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SI-8911973-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e9445e5e3626f36e932c6451a928250 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-732 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-11 |
| filingDate | 1989-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a221731e0a656fd4b4e60c101db142f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a67a0c19db81eeec6c292d11e22f6d6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_739703eea984747e125e55b6869da991 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4890a5c182c1cf8b575bd9356d3ff08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf155a3e67dd3c1839b5ecb4482d6e9c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32223e47bdb0aa7ba9ee8ece5a6e2d8e |
| publicationDate | 1997-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SI-8911973-A |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF 7-SUBSTITUTED-HEPT-6-EOIC AND HEPTANIC ACIDS AND THEIR DERIVATIVES AND INTERMEDIATES |
| abstract | A process for the preparation of 7-substituted hept-6-enenand heptanoic acids and their derivatives and intermediates.nA new process for the preparation of compounds of formula I is described:n5 3nR - X - CH - CHj - CH - CHj - COORinOH OHnwherein X is -CH 2 CH 2 - or -CH = CH-; Ri ester group, inertnfor reaction conditions; and R is an organic residue with groups whichnthey are inert under reducing conditions; with stereoselective reductionnthe corresponding compounds of formula II:nR - X - C - CBj - C - CHj - COORi I 'II 1nZi Zjnwhere R, Ri and X are as defined above and is one of Z1 and Z2noxygen and other hydroxy and hydrogen,. The compounds of formula I arenpharmacists, in particular anti-atherosclerotic, antihyperlipidemicnand antihypercholesterolemic agents. The process can alsonused to prepare compounds of formula lu:nin - OCHj - CHCHjCHCHj - C00RunOH OHnwhere u is triphenylmethyl (trityl) and Ru is allyl or an ester forming residue,ninert under reaction conditions which are intermediates in the preparationnsome of the compounds of formula I. New processes are also describednfor preparing the above intermediates for use in the preparationnamong others compounds of formula I, namely process A comprisingnpreparation of compounds of formula VII:n(E) - OHC - CH = CH - N (Ri2) Ri3nwherein R12 is C1-3 alkyl, phenyl or phenyl substituted with 1 to 3nsubstituents, each of which is independently C1-3 alkyl, C1-3-nalkoxy, fluoro, chloro, bromo or nitro with a maximum of two nitrongroups; and R13 has the independent meaning indicated above fornR12, from the corresponding compounds of formula Vlil:nOHC - N (Ri2) Ri3nand method B, which comprises the preparation of compounds of formula Va:n, wherein R 5 is hydrogen, C 1-3 alkyl, n-butyl, i-butyl, t-butyl, C 3 -cycloalkyl,nC1-3alkoxy, n-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro,nphenoxy or benzyloxy; R 1 is hydrogen, C 1-3 alkyl, C 1-3 alkoxy, trifluoromethyl,nfluoro, chloro, phenoxy or benzyloxy; with reservations, yesnis not more than one of R5 and R6 trifluoromethyl, not more than onenof R5 and R6 are phenolic and not more than one of R5 and R6 is benzyloxy;none of R7 and Re is phenyl trisubstituted by Rg, R10 and Ri1 and the othernprimary or secondary C 1-6 alkyl containing no asymmetricncarbon atoms, C3-cycloalkyl or phenyl- (CH2) m-, wherenRg is hydrogen, C1-3alkyl, n-butyl, i-butyl, t-butyl, Cisalkoxy,nn-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro, phenoxy ornbenzyloxy; R10 is hydrogen, C1-3alkyl, C1-3alkoxy, trifluoromethyl,nfluoro, chloro, phenoxy or benzyloxy; R11 is hydrogen, C1-2alkyl,nCisalkoxy, fluoro or chloro and m is 1, 2 or 3; with the reservation that it is notnmore than one of Rg and R10 trifluoromethyl, not more than one of Rgnand R10 is phenolic and is not more than one of Rg and R10 benzyloxy; fromnsubgroups of compounds of formula VII. Specific implementation of the abovenan inventive concept is shown by preparing the compoundnwith the formula la:nin racemic or optically pure form; in the form of free acid, salt,nof ester or delta-lactone, i.e. of the internal ester. |
| priorityDate | 1988-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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