http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SI-23508-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_276164141bff1b671b52ceb89dd1b779 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_04eb64add4be0101b3be0da7a11e9b29 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate | 2010-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cde7137aaeab8a47e924bd9d4ca034c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_781157c0e1c13fbb07f60b7aa46a4f6a |
| publicationDate | 2012-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SI-23508-A |
| titleOfInvention | A fusion polypeptide consisting of a TIR domain and a dimerization domain for the modulation of TLR / natural immunity signaling |
| abstract | The invention provides inhibitory fusion polypeptides consisting of a TIR domain and a dimerization domain for the inhibition of TLR / IL-1R signaling pathways consisting of a TIR domain and a dimerization domain, wherein the two domains are associated with the binding peptide and wherein the polypeptide optionally also comprises a segment for membrane localization. Addition of the dimerization domain to the TIR domain significantly improves the inhibitory potential of the TIR domain. The invention also provides the use of a nucleic acid encoding a fusion-like polypeptide consisting of a TIR domain and a dimerization domain, or the use of a recombinantly produced fusion polypeptide consisting of a TIR domain and a dimerization domain, the particular use of a polypeptide additionally comprising a protein transduction domain for inhibiting cellular signaling TLR / IL-1R or for the preparation of a medicament for the treatment of chronic or acute inflammatory conditions such as infectious and autoimmune diseases, sepsis, septic shock, cancer, and others resulting from inadequate and / or signaling TLR / IL-1R. |
| priorityDate | 2010-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 539.