| abstract |
New glycocorticoid and thyroid receptor ligands of general formula (I) are presented wherein R1 is an aliphatic hydrocarbon, aromatic hydrocarbon, carboxylic acid or ester, alkenyl carboxylic acid or ester, hydroxy, halogen or cyano or pharmaceutically acceptable salt thereof. R2 and R3 are the same or different and represent hydrogen, halogen, alkyl of 1 to 4 carbons, or cycloalkyl of 3 to 5 carbons, at least one of R2 and R3 being not hydrogen. X is carbonyl or methylene. R4 is aliphatic, aromatic or heteroaromatic. Y is hydroxyl, methoxy, amino or alkyl amino, n is an integer from 0 to 4. Also disclosed is a method using these compounds to treat diseases that are associated with metabolic dysfunction or are glucocorticoid or thyroid dependent receptor gene (such as diabetes, hypercholesterolemia and obesity) .ŕ |