| abstract |
Disclosed are therapeutically active xanthine derivatives of formula (I) or pharmaceutically acceptable salts or solvates thereof, wherein R1 is selected from: hydrogen and C1-4 alkyl which may be optionally substituted with one or more groups selected from CN and CF3; R2 is selected from: C3-10 unsubstituted alkyl, C1-10 alkyl substituted with one or more groups selected from fluorine and CN, C5 alkenyl, unbranched C4 alkenyl, and C1-4 alkyl substituted with cycloalkyl; and R3 represents chlorine; as well as processes for their manufacture, pharmaceutical compositions containing them, and their use in therapy, particularly in the treatment of diseases where under-activation of the HM74A receptor contributes to the disease or where activation of the receptor will be beneficial, including the treatment of disorders of lipid metabolism. |