http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SG-11201908322W-A
Outgoing Links
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|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 |
| filingDate | 2018-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0722a254a4256f6ab3902bf2ca9216c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_674eb1b0af7f0df1a06fb613540a326c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd2539dde8013f46dd12c41fe0cc5b7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec79cce349dba23158f6e654ca9eb17a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_354abf02afa53839ff36e868061b29d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70e11cab7fc001615fa5064301b2db3e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86644adef04877f470858eb0dd4e836f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76b6e883ff0b681268e5f1d68c2d72a9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67552b7b38aea238f899d93ce62fa988 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c48f17781d4223722361645dbdbe4a4b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82b2f2e70bb239496706bb4254813965 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46a4f82f754636b5329d0357838cc68f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82694e3f0301ec8f114448cdaa5bdd9d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53821e4a1cd33e5dbb47e1d97b228ac3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be738a975812b9fe1a9d10fa217533cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33bfb363fdd7f61c918d41184452e388 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6d27c5a2f31d506ddd24ae1d8296c7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87a9d5c4e11cd621a1fba504e631179e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_493a49dbe7622d131f99e6a0c718560b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef78ab61e2a7f51f5ac1f77a4abb6765 |
| publicationDate | 2019-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SG-11201908322W-A |
| titleOfInvention | Novel imidazo[4,5-c]quinoline derivatives as lrrk2 inhibitors |
| abstract | International Patent Classification: CO7D 471/04 (2006.01) A61P 25/16 (2006.01) CO7D 519/00 (2006.01) A61P 25/28 (2006.01) A61K 31/437 (2006.01) A61P 25/18 (2006.01) (21) International Application Number: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 13 September 2018 (13.09.2018) WIPO I PCT ~~ll~~~~~~~~ 011101010VIIIOH olo omio111111111flo ow (10) International Publication Number WO 2018/163066 Al PCT/IB2018/051439 (22) International Filing Date: 06 March 2018 (06.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/469,756 10 March 2017 (10.03.2017) US 62/629,152 12 February 2018 (12.02.2018) US (71) Applicant: PFIZER INC. [US/US]; 235 East 42nd Street, New York, New York 10017 (US). (72) Inventors: BRODNEY, Michael Aaron; 100 Upland Av- enue, Newton, Massachusetts 02461 (US). CHAPPIE, Thomas Allen; 59 Hemlock Hill Road, Carlisle, Massachu- setts 01741 (US). CHEN, Jinshan Michael; 39 Governors Way, Madison, Connecticut 06443 (US). COE, Jotham Wadsworth; 8 Bush Hill Drive, Niantic, Connecticut 06357 (US). COFFMAN, Karen Jean; 3 Clarence Ave., Paw- catuck, Connecticut 06379 (US). GALATSIS, Paul; 375 Cherry Street, Newton, Massachusetts 02465 (US). GAR- NSEY, Michelle Renee; 386 Morris Ave., Providence, Rhode Island 02906 (US). HELAL, Christopher John; 18 Elm Street, Mystic, Connecticut 06355 (US). HEN- DERSON, Jaclyn Louise; 36 Highland Avenue, Apt. 54, Cambridge, Massachusetts 02139 (US). KORMOS, Bethany Lyn; 46 Quincy Street, #3, Somerville, Massa- chusetts 02143 (US). KURUMBAIL, Ravi G.; 4 Harvest Glen, East Lyme, Connecticut 06333 (US). MARTINEZ- Declarations under Rule 4.17: ALSINA, Luis Angel; 58 Eagle Ridge Drive, Gales Ferry, Connecticut 06335 (US). PETTERSSON, Mar- tin Youngjin; 3 Gilson Road, Littleton, Massachusetts 01460 (US). REESE, Matthew Richard; 25 Ocean View Avenue, Mystic, Connecticut 06355 (US). ROSE, Colin Richard; 35 B Lower Bartlett Road, Quaker Hill, Connecti- cut 06375 (US). STEPAN, Antonia Friederike; Rotdorn- weg 8, 88400 Biberach An Der Riss (DE). VERHOEST, Patrick Robert; 23 Calvin Road, Newton, Massachusetts 02460 (US). WAGER, Travis T.; 465 Washington Street, Apt. 6, Brookline, Massachusetts 02446 (US). WARMUS, Joseph Scott; 18 Sable Drive, Ledyard, Connecticut 06339 (US). ZHANG, Yuan; 12103 Maple Tree Lane, East Lyme, Connecticut 06333 (US). (74) Agent: WALDRON, Roy F.; Pfizer Inc., 235 East 42nd Street, MS 235/9/S20, New York, New York 10017 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) W O 20 18/ 163066 Al (54) Title: NOVEL IMIDAZO[4,5-C]QUINOLINE DERIVATIVES AS LRRK2 INHIBITORS (57) : The present invention provides novel imidazo[4,5-c]quinoline derivatives of Formula (I), and the pharmaceutically acceptable salts thereof I wherein R 1 , R 2 and R 3 are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of Formula I and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's dis- ease or Alzheimer's disease, cancer, Crohn's disease or leprosy. (I) [Continued on next page] WO 2018/163066 Al MIDEDIMOMMIDIIMEIEWHIDIENIEMIEMOVOIS Published: with international search report (Art. 21(3)) in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE |
| priorityDate | 2017-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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