http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SG-11201900595Y-A

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filingDate 2017-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed58b39bb127763706836ca3c1b281be
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publicationDate 2019-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber SG-11201900595Y-A
titleOfInvention Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells
abstract INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 February 2018 (08.02.2018) WIP0 I PCT Hu onus °nolo omolomioom °num ow (10) International Publication Number WO 2018/026715 Al (51) International Patent Classification: C07K 14/47 (2006.01) C12N 15/10 (2006.01) C12N 15/09 (2006.01) C12N 15/39 (2006.01) (21) International Application Number: PCT/US2017/044688 (22) International Filing Date: 31 July 2017 (31.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/370,009 02 August 2016 (02.08.2016) US (71) Applicant: VACCINEX, INC. [US/US]; 1895 Mt. Hope Avenue, Rochester, New York 14620 (US). (72) Inventors: SMITH, Ernest; 101 Brittany Lane, Pittsford, New York 14534 (US). SHI, Shuying; 169 Shelboume Rd., Rochester, New York 14620 (US). (74) Agent: HAANES, Elizabeth J. et al.; Thompson Coburn LLP, One US Bank Plaza, St. Louis, Missouri 63101 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) 1-1 with sequence listing part of description (Rule 5.2(a)) 11 N © (54) Title: IMPROVED METHODS FOR PRODUCING POLYNUCLEOTIDE LIBRARIES IN VACCINIA VIRUS/EUKARYOTIC 00 CELLS 1-1 0 (57) : This disclosure provides an improved method of constructing a library of polynucleotides of interest in a poxvirus, e.g., \" vaccinia virus vector system, where the polynucleotides of interest encode polypeptides of interest. The method comprises constructing C the library in the presence of an inhibitor of poxvirus assembly, e.g., rifampicin, which allows construction of libraries with higher complexity and diversity than previous methods.
priorityDate 2016-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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