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filingDate 2017-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8cc369a7e7d8f647d9c6147a6f08b8f1
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publicationDate 2018-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber SG-11201809605P-A
titleOfInvention Compositions for and method of treating acid-base disorders
abstract INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111111101011111111111 0111011111111111101100111111101111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .......'\" WO 2017/193064 Al 09 November 2017 (09.11.2017) W I P0 I P C T (51) International Patent Classification: (72) Inventors: KLAERNER, Gerrit; c/o Tricida, Inc., 7000 A61K 31/13 (2006.01) A61K 9/10 (2006.01) Shoreline Court, Suite 201, South San Francisco, Califor- A61K 9/00 (2006.01) A61K 9/20 (2006.01) nia 94080 (US). CONNOR, Eric F.; c/o Tricida, Inc., 7000 A61K 9/14 (2006.01) Shoreline Court, Suite 201, South San Francisco, Califor- (21) International Application Number: nia 94080 (US). GBUR, Randi K.; c/o Tricida, Inc., 7000 PCT/US2017/031395 Shoreline Court, Suite 201, South San Francisco, California 94080 (US). KADE, Matthew J.; c/o Tricida, Inc., 7000 (22) International Filing Date: Shoreline Court, Suite 201, South San Francisco, Califor- 05 May 2017 (05.05.2017) nia 94080 (US). KIERSTEAD, Paul H.; c/o Tricida, Inc., 7000 Shoreline Court, Suite 201, South San Francisco, Cal- (25) Filing Language: English ifornia 94080 (US). BUYSSE, Jerry M.; c/o Tricida, Inc., (26) Publication Language: English 7000 Shoreline Court, Suite 201, South San Francisco, Cal- ifornia 94080 (US). COPE, Michael J.; c/o Tricida, Inc., (30) Priority Data: 7000 Shoreline Court, Suite 201, South San Francisco, Cal- 62/333,059 06 May 2016 (06.05.2016) US ifornia 94080 (US). BIYANI, Kalpesh N.; c/o Tricida, Inc., 62/350,686 15 June 2016 (15.06.2016) US 7000 Shoreline Court, Suite 201, South San Francisco, Cal- 62/408,885 17 October 2016 (17.10.2016) US ifornia 94080 (US). NGUYEN, Son H.; c/o Tricida, Inc., 62/414,966 31 October 2016 (31.10.2016) US 7000 Shoreline Court, Suite 201, South San Francisco, Cal- (71) Applicant: TRICIDA, INC. [US/US]; 7000 Shoreline ifornia 94080 (US). TABAKMAN, Scott M.; c/o Tricida, Court, Suite 201, South San Francisco, California 94080 Inc., 7000 Shoreline Court, Suite 201, South San Francisco, (US). California 94080 (US). = = (54) Title: COMPOSITIONS FOR = = = = = _ AND METHOD OF TREATING ACID-BASE DISORDERS • —•-•— Placebo (Nr-25) ----1.5 gld BID (1\145) ---- 3.0 gld BID (N=25) 4.5 BID — w 21 = E 20 cf, = 'b = co w 19 = ' 18 = 17 = 16 o it gld (N=26) 0 l 1 . i • = BL 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 17 21 24 28 Study Day mo d ' FIG. 7 ii- © M C:N (57) : Pharmaceutical compositions for and methods of treating an animal, including a human, and methods of preparing 1-1 ----. such compositions. The pharmaceutical compositions contain nonabsorbable compositions and may be used, for example, to treat ir---- diseases or other metabolic conditions in which removal of protons, the conjugate base of a strong acid and/or a strong acid from the 1-1 Q gastrointestinal tract would provide physiological benefits such as normalizing serum bicarbonate concentrations and the blood pH in el an animal, including a human. C [Continued on next page] WO 2017/193064 Al MIDEDIMOMOIDEIRMEMOMOMEDIMINHEMOMIDIME (74) Agent: COTTON, Abigail; c/o Bryan Cave LLP, 211 North Broadway, Suite 3600, St. Louis, Missouri 63102 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))
priorityDate 2016-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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