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filingDate 2017-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2018-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber SG-11201806700R-A
titleOfInvention Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof
abstract INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) CORRECTED VERSION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 17 August 2017 (17.08.2017) WiP0 I PCT 111111111111011010101111101011111 0 01110011011104011011101110# (10) International Publication Number WO 2017/136870 A9 (51) International Patent Classification: CO7D 471/04 (2006.01) A61K 31/404 (2006.01) CO7D 413/04 (2006.01) A61P 1/16 (2006.01) CO7D 405/04 (2006.01) A61P 9/00 (2006.01) CO7D 403/04 (2006.01) A61P 13/12 (2006.01) CO7D 401/04 (2006.01) A61P 29/00 (2006.01) CO7D 209/10 (2006.01) A61P 35/00 (2006.01) A61K 31/33 (2006.01) (21) International Application Number: PCT/AU2017/000039 (22) International Filing Date: 10 February 2017 (10.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 2016900478 12 February 2016 (12.02.2016) AU 2016902593 01 July 2016 (01.07.2016) AU (71) Applicant: PHARMAXIS LTD. [AU/AU]; 20 Rodbor- ough Road, Frenchs Forest, NSW 2086 (AU). (72) Inventors: FINDLAY, Alison Dorothy; 20 Rodbor- ough Road, Frenchs Forest, NSW 2086 (AU). TURN- ER, Craig Ivan; 20 Rodborough Road, Frenchs For- est, NSW 2086 (AU). DEODHAR, Mandar; 20 Rod- borough Road, Frenchs Forest, NSW 2086 (AU). FOOT, Jonathan Stuart; 20 Rodborough Road, Frenchs Forest, NSW 2086 (AU). JAROLIMEK, Wolfgang; 20 Rodbor- ough Road, Frenchs Forest, NSW 2086 (AU). ZHOU, Wenbin; 20 Rodborough Road, Frenchs Forest, NSW 2086 (AU). ROBERTSON, Alan Duncan; 12 Cherry Street, Warrawee, NSW 2074 (AU). (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (48) Date of publication of this corrected version: 15 February 2018 (15.02.2018) (15) Information about Correction: see Notice of 15 February 2018 (15.02.2018) W O 20 17 / 13687 0 A9 (74) Agent: SPRUSON & FERGUSON; GPO Box 3898, Syd- ney, New South Wales 2001 (AU). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (54) Title: HALOALLYLAMINE INDOLE AND AZAINDOLE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF (57) : The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.
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