| abstract |
AZOLE-SUBSTITUTED PYRIDINE COMPOUND The present invention provides a compound represented by formula [I] shown below or a pharmaceutically acceptable salt thereof that has an inhibitory effect on 20-HETE producing enzyme, wherein the structure represented by formula [III] shown below represents any of the structures represented by formula group [IV] shown below, wherein IV represents a hydrogen atom, a fluorine atom, methyl, etc.; R 2 , R 3 , and R 4 each independently represent a hydrogen atom, a fluorine atom, or methyl; W represents a single bond, Ci-3alkanediyl, or the formula -0-CH2CH2-; and ring A represents (a) substituted C4_6cycloalkyl, (b) substituted 4- to 6-membered saturated nitrogen-containing heterocyclyl, (c) substituted phenyl, (d) substituted pyridyl, (e) substituted 2,3-dihydrobenzofuran, (f) 4- to 6-membered saturated oxygen-containing heterocyclyl, etc. [Formula I] ring R 4 N B W , R 1 ring O R 2 A R3 Y [r] [Formula 2] ring B R 1 [III] [Formula 3] HN — N _N N - -7-N \ Nz - -N, HN — N, NH , ,,, ,.. z . ---- -R 1 NH N_ '( '=',:. . - 1 1- N R 1 , N \"- --\ r _—N s r N S—N S -!,,LN...,f—N ,,i_NI..,f,N — \ --- R 1 , R1 [W] |