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filingDate 2016-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_087c6eddd057c03e2f2334f50a060e9e
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publicationDate 2018-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber SG-11201804223T-A
titleOfInvention OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF
abstract INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau res., 00) (43) International Publication Date ..... ..sr.1 1 June 2017 (01.06.2017) WIPO I PCT ID Hit (10) 1111111111111111111 WO International Ell DION 2017/088759 Publication WHIM 11111 Ill Al Number RIIIIIIIIIIIIIII (51) International Patent Classification: (74) Agent: TSINGYIHUA INTELLECTUAL PROPERTY C07D 487/04 (2006.01) A61P 25/18 (2006.01) LLC; Room 301, Trade Building, Zhaolanyuan, Tsinghua A61K 31/517 (2006.01) A61P 1/00 (2006.01) University, Qinghuayuan, Haidian District, Beijing 100084 A61K 31/423 (2006.01) A61P 29/00 (2006.01) (CN). A61P 25/20 (2006.01) A61P 9/00 (2006.01) A61P 25/24 (2006.01) A61P 3/10 (2006.01) (81) Designated States (unless otherwise indicated, for every A61P 25/22 (2006.01) A61P 37/02 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, PCT/CN2016/106937 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (22) International Filing Date: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 23 November 2016 (23.11.2016) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (26) Publication Language: English TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (30) Priority Data: ZW. 201510823712.8 23 November 2015 (23.11.2015) CN (84) Designated States (unless otherwise indicated, for every (71) Applicant: SUNSHINE LAKE PHARMA CO., LTD. kind of regional protection available): ARIPO (BW, GH, [CN/CN]; Northern Industrial Area, Songshan Lake, Dong- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, guan, Guangdong 523000 (CN). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (72) Inventors . ZHANG, Yingjun; Dongyangguang Hi-tech DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Park, Zhen An Road No.368, Shang Sha, Chang An Town, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Dongguan, Guangdong 523871 (CN). JIN, Chuanfei; SM, TR), OAPI BJ, CF, CG, CI, CM, GA, GN, GQ, (BF, Dongyangguang Hi-tech Park, Zhen An Road No.368, GW, KM, ML, MR, NE, SN, TD, TG). Shang Sha, Chang An Town, Dongguan, Guangdong Published: 523871 (CN) ZHANG, Ti; Dongyangguang Hi-tech Park, Zhen An Road No.368, Shang Sha, Chang An Town, — with international search report (Art 21(3)) Dongguan, Guangdong 523871 (CN). Il .4t C\ In IN GC GC C::: , IN 1-1 (54) Title: OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF 0 N (57) : The invention relates to octahydropyrrolo [3, 4-c] pyrrole derivatives and uses thereof. Compounds and pharmaceut- ical compositions comprising the compounds provided herein are used for antagonizing orexin receptors. The invention also relates to processes for preparing the compounds and pharmaceutical compositions, and uses thereof in treating or preventing a disease re- lated to orexin receptors.
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