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filingDate 2013-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13e282169d00f3d48db788f662c47405
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publicationDate 2015-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber SG-11201408090Q-A
titleOfInvention Pyrimidinone derivatives as antimalarial agents
abstract (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 December 2013 (27.12.2013) WIPOIPCT (10) International Publication Number WO 2013/190123 A1 (51) International Patent Classification: C07D 487/04 (2006.01) A61P 33/00 (2006.01) A61K31/519 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/EP2013/063065 21 June 2013 (21.06.2013) English English (30) Priority Data: 12559258 22 June 2012 (22.06.2012) FR (71) Applicant: SANOFI [FR/FR]; 54 rue La Boetie, F-75008 Paris (FR). (72) Inventors: EL-AHMAD, Youssef; Sanofi, Patent Depart­ ment, 54 rue La Boetie, F-75008 Paris (FR). FILOCHE- ROMME, Bruno; Sanofi, Patent Department, 54 rue La Boetie, F-75008 Paris (FR). GANZHORM, Axel; Sanofi, Patent Department, 54 rue La Boetie, F-75008 Paris (FR). MARCINIAK, Gilbert; Sanofi, Patent Department, 54 rue La Boetie, F-75008 Paris (FR). MUZET, Nicolas; Sanofi, Patent Department, 54 rue La Boetie, F-75008 Paris (FR). RONAN, Baptiste; Sanofi, Patent Department, 54 rue La Boetie, F-75008 Paris (FR). VIVET, Bertrand; Sanofi, Patent Department, 54 rue La Boetie, F-75008 Paris (FR). ZERR, Veronique; Sanofi, Patent Department, 54 rue La Boetie, F-75008 Paris (FR). (74) Agent: CATILLON, Marie; Sanofi, Patent Department, 54 rue La Boetie, F-75008 Paris (FR). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) (54) Title: PYRIMIDINONE DERIVATIVES AS ANTIMALARIAL AGENTS (I) m CJ T-H o o\ T-H rn i-H (57) Abstract: The invention relates to novel pyrimidinone-based heterocyclic compounds which are parasite growth inhibitors, hav- O ing the general formula (I) in which Y is a morpholine chosen from three bridged morpholines, L is a bond or a linker, n = 0 or 1 and ^ R2 is a methyl group when n = 0 and a hydrogen atom when n = 1. Process for the preparation thereof and therapeutic use thereof.
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Total number of triples: 47.