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filingDate 2012-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69e1da95aeeef8f110e23ef23827e142
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publicationDate 2014-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber SG-11201402826Y-A
titleOfInvention Substituted nucleosides, nucleotides and analogs thereof
abstract (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 June 2013 (27.06.2013) WIPOIPCT (10) International Publication Number WO 2013/096679 A1 (51) International Patent Classification: C07H19/00 (2006.01) C07H19/06 (2006.01) C07H19/14 (2006.01) C07H19/16 (2006.01) A61K31/4184 (2006.01) A61K31/522 (2006.01) A61K31/506 (2006.01) A61K31/4192 (2006.01) C07D 471/04 (2006.01) C07D 473/34 (2006.01) A61P 31/14 (2006.01) C12N 9/99 (2006.01) A61K31/675 (2006.01) A61K31/708 (2006.01) A61K31/7068 (2006.01) A61K31/7072 (2006.01) (21) International Application Number: PCT/US2012/071063 20 December 2012 (20.12.2012) (22) International Filing Date: 2 (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 61/579,560 22 December 2011 (22.12.2011) US 61/613,836 21 March 2012 (21.03.2012) US (71) Applicant: ALIOS BIOPHARMA, INC. [US/US]; 260 E. Grand Ave. 2nd Floor, South San Francisco, CA 94080 (US). (72) Inventors: BEIGELMAN, Leonid; 991 East Grant Place, San Mateo, CA 94402 (US). WANG, Guangyi; 5066 Mil- lay Court, Calsbad, CA 92008 (US). SMITH, David, Bernard; 218 W. 40th Avenue, San Mateo, CA 94403 (US). DEVAL, Jerome; 143 Carmel Ave., Pacifica, CA 94044 (US). PRHAVC, Marija; 1122 Cambria Way, En- cinitas, CA 92024 (US). (74) Agent: MILLER, Kimberly, J.; Knobbe Martens Olsen & Bear LLP, 2040 Main Street, 14th Floor, Irvine, CA 92614 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). [Continued on next page] (54) Title: SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF Figure 1 o\ 0\ © rn T-H o CJ Compound BMS-433771 TMC-353121 Structure (57) Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating disease and/or a a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, nucleotide a and an analog thereof. WO 2013/096679 A11 lllll llllllll II llllll III lllll lllll III III III lllll lllll lllll lllll lllll llll llll lllllll llll llll u ls e ' — before the expiration of the time limit for amending the — with international search report (Art. 21(3)) claims and to be republished in the event of receipt of amendments (Rule 48.2(h))
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