| abstract |
A process for preparing flecainide comprises reacting para-dibromo- benzene or para-dihydroxybenzene with a compound of formula CF3CH2O- A wherein A is -SO2CF3 or an alkali metal, acetylating the resulting 1,4- bis(trifluoroethoxy) benzene to give the bis (trifluoroethoxy) acetophenone in the presence of a Lewis acid catalyst, then either chlorinating the acetylated product, adding a buffering base and further chlorinating to form the corresponding alpha , alpha , alpha -trichloroacetophenone or reacting the acetylated acetophenone with hypochlorite to form the corresponding benzoic acid and reacting the acid with an inorganic acid chloride to provide the corresponding acid chloride, and then reacting the product of either of the latter pair of steps with 2-amino-methyl-piperidine to form the flecainide product in one step or with two 2-amino-methyl- pyridine followed by reduction to form the flecainide product in two steps. Individual reaction steps in the above scheme are presented as being novel per se, as are some of the intermediate compounds formed. |