http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SE-8602737-D0

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publicationDate 1986-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber SE-8602737-D0
titleOfInvention PROCESS FOR THE PREPARATION OF 2-HALONICERGOLINE DERIVATIVES AND THEIR ACID ADDITION SALTS AND NEW 2-HALONICERGOLINES
abstract The invention relates to a novel process for the preparation of partially new 2-halonicergoline derivatives of the formula (I), <IMAGE> (I) wherein X stands for chlorine, bromine or iodine atom, as well as their acid addition salts. The process of the invention comprises esterifying a novel 2-halo-1-methyllumilysergol of the formula (II), <IMAGE> (II) wherein X is the same as defined above, or an acid addition salt thereof and, if desired, converting the thus-obtained 2-halonicergoline derivative of the formula (I) to an acid addition salt. The compounds of the invention improve the cognitive function of the brain and show an antihypoxic as well as a strong alpha -adrenerg blocking and calcium-antagonistic action.
priorityDate 1985-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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Total number of triples: 42.