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filingDate 1986-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d8815cee2bd5c1f97d3a9c9912a22be
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publicationDate 1986-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber SE-8601826-D0
titleOfInvention 5-PYRIMIDINECARBOXAMIDES AND TREATMENT OF LEUKEMIA AND TUMORS THEREWITH
abstract Novel 5-pyrimidinecarboxamides useful for regressing or inhibiting the growth of leukemia and tumors. The compounds have the formula: <IMAGE> wherein R1 is hydrogen or an alkoxy group having from one to four carbon atoms; R2 is hydrogen; alkyl, aryl, aralkyl, allyl, aralkenyl or aralkynyl, the alkyl, alkenyl or alkynyl moieties of which have from one to six carbon atoms, or a carbohydrate residue; R3 is hydrogen, C1-C4 alkyl or aryl; R4 is phenyl, naphthyl, benzyl, naphthylmethyl, thienyl, thienylmethyl or pyridyl; or phenyl, naphthyl, benzyl, naphthylmethyl, thienyl, thienylmethyl or pyridyl substituted with one or more of the following groups: hydroxy; halo; alkyl, alkoxy, alkylthio, haloalkyl or haloalkoxy having from one to four carbon atoms; carboxy; alkoxycarbonyl having from two to five carbon atoms; nitro; cyano; aryl; aryloxy; arylthio; benzyl; benzyloxy; naphthylmethyl; naphthylmethyloxy; thienyl; or thienylmethyl; and Y and Z are each independently oxygen, sulfur or selenium; and the pharmacologically acceptable addition salts thereof.
priorityDate 1985-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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