| abstract |
The invention relates to new apovincaminol derivatives of the formula /I/ <IMAGE> (I) wherein R1 is hydrogen, nitro or halogen, R2 is a substituted or unsubstituted alkyl or phenyl group, R3 and R4 together form a valency bond or each independently represents hydrogen, hydroxyl or an -OR5 group, in which R5 is substituted or unsubstituted alkanoyl or benzoyl group, with the proviso that if R2 stands for a 3,4,5-trimethoxyphenyl group and R1 is hydrogen, R3 and R4 together do not form a valency bond, or if R2 is a 3,4,5-trimethoxyphenyl group and R3 and R4 both are hydrogen, R1 is other than hydrogen, nitro or bromine, and acid addition salts thereof. The compounds may be used in the therapy of various skin diseases accompanied by a pathological cell proliferation, preferably psoriasis. |