http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SE-8400145-D0
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bfc91c967e885ba5b44b7ad5278367f8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-0015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-0085 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 1984-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07df0e01f02077f4620047dacf76d8ec |
| publicationDate | 1984-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SE-8400145-D0 |
| titleOfInvention | PROCESS FOR THE PRODUCTION OF 17-ESTERS OF CLOBETASOL |
| abstract | PROCESS FOR THE PRODUCTION OF 17-ESTERS OF CLOBETASOL This invention relates to an improved process for the preparation of 17-esters of Clobetasol having the formula <IMG> II which consists in treatment of 9.beta.,11.beta.-epoxy-16.beta.-methyl-pregna-1,4-diene-17,21-diol-3,20-dione 17-esters with mesyl chloride to give the corresponding 21-chloro-deriv-ative, followed by opening of the epoxide grouping with hydrogen fluoride. The invention also relates to new 17-esters of 21-chloro-9.beta.,11.beta.-epoxy-17-hydroxy-16.beta.-methyl-pregna-1,4-diene-3,20-dione, useful as intermediates for the preparation of therapeutically active 9.alpha.-halo-11.beta.-hydroxy derivatives. |
| priorityDate | 1983-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 19.