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publicationDate 1983-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber SE-8302075-D0
titleOfInvention Vasopressin analogues
abstract Vasopressin analogs of the formula <IMAGE> wherein R1 is H, R2 is CH2S and R3 is D-Arg, R1 is NH2, R2 is S-S and R3 is D-Arg or L-Orn are described. The described analogs resist enzymatic cleavage while retaining their effect on the central nervous system. These compounds lack a glycinamide residue in the 9 position and have the L-arginine in the 8 position replaced with its stereoisomeric form or with an ornithine residue. The compounds evidence little or no peripheral endocrine effects of natural vasopressin.
priorityDate 1982-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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